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ICONC13277 Alvimopan(ADL-8-2698,LY-246736) (170098-38-1)
 
 
Catalog No.: C13277
CAS No.: 170098-38-1
Synonym: ADL-8-2698, LY-246736 dihydrate
Chemical Name:

N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine dihydrate

Molecular Formula:

C25H32N2O4.2(H2O)

Molecular Weight: 460.57
 
Technical Data:
Appearance: White or off-white crystal
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Alvimopan(ADL-8-2698,LY-246736):

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Biological Activity:

ADL-8-2698 is a novel peripherally restricted opioid antagonist that may selectively prevent opioid-induced gastrointestinal effects without reversing analgesia. Alvimopan reduces certain side effects of narcotic medications that are often used to prevent pain caused by surgery.Narcotic medications can cause stomach pain, bloating, nausea, vomiting, and constipation. These side effects can delay recovery in patients undergoing gastrointestinal surgery. Alvimopan works by preventing these side effects without reducing the pain-relieving effects of the narcotic. Alvimopan is used to speed recovery of stomach and intestinal functions after a gastrointestinal surgery and to prevent side effects caused by narcotic medications. Alvimopan may also be used for other purposes not listed in this medication guide.

 

 
References:
Delaney CP, et al. Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis Colon Rectum. 2005 Jun;48(6):1114-25; discussion 1125-6; author reply 1127-9.
 
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