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ICONC14347 WZ 4002(WZ-4002) (1213269-23-8)
 
 
Catalog No.: C14347
CAS No.: 1213269-23-8
Synonym:
Chemical Name:
N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
Molecular Formula: C25H27ClN6O3
Molecular Weight: 494.97
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO,water and ethanol
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of WZ 4002(WZ-4002):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:

WZ 4002 is an inhibitor of EGFR phosphorylation in a variety of cancer cell lines including NIH-3T3 and H1975 cells. WZ 4002 is a potent inhibitor of EGFR, exhibiting an IC50 = 2 nM. This induces apoptosis in the cell due to the blocking of signal transduction from EGFR.

 
References:
1. Zhou W, et al. Nature. 2009, 462(7276), 1070-1074.
 
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