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C13932 Nigericin(Nigericin sodium salt) (28643-80-3)

Catalog No.:	C13932
CAS No.:	28643-80-3
Synonym:	Nigericin sodium salt
Chemical Name:	Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate
Molecular Formula:	C₄₀H₆₇NaO₁₁
Molecular Weight:	746.94

Technical Data:

Appearance:
Solubility:	Soluble in ethanol
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Nigericin(Nigericin sodium salt):

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

Potassium ionophore, exchanges K⁺ for H⁺ across biological membranes, in a similar manner toValinomycin (Cat. No. 3373). Stimulates mitochondral ATPase activity and disrupts membrane potential. Also acts as an ionophore for Pb²⁺ with no activity with other divalent cations. Antibiotic derived from Streptomyces hygroscopius.

References:

1. Myskiw C et al. Nigericin is a potent inhibitor of the early stage of vaccinia virus replication. Antiviral Res88:304-10 (2010).

2. Margolis LB et al. K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells. Proc Natl Acad Sci U S A 86:6626-9 (1989).

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