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C14316 Vandetanib(AZD6474) (443913-73-3)

Catalog No.:	C14316
CAS No.:	443913-73-3
Synonym:	AZD6474;ZD6474;Zactima;ZD-6474;AZD-6474;Caprelsa;4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline
Chemical Name:	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Molecular Formula:	C₂₂H₂₄BrFN₄O₂
Molecular Weight:	475.35

Technical Data:

Appearance:	White powder
Solubility:	Soluble in DMSO
Purity:	HPLC>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Vandetanib(AZD6474):

Size	Price	Stock
100mg	USD86	In Stock
500mg	USD260	In Stock
1g	USD450	In Stock

Biological Activity:

A orally bioavailable tyrosine kinase inhibitor (TKI), targeting VEGFR and EGFR; a potential medication for non-small-cell lung cancer.

References:

1. RS Herbst et al. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin. Investig. Drugs. 2007, 16, 239-249.

2. SR Wedge et al. ZD6474 Inhibits Vascular Endothelial Growth Factor Signaling, Angiogenesis, and Tumor Growth following Oral Administration. Cancer Res. 2002, 62, 4645-4655.

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