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C13986 Pazopanib(GW-786034) (444731-52-6)

Catalog No.:	C13986
CAS No.:	444731-52-6
Synonym:	GW786034;GW 786034;Votrient;Armala
Chemical Name:	5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide
Molecular Formula:	C₂₁H₂₃N₇O₂S
Molecular Weight:	437.52

Technical Data:

Appearance:	White powder
Solubility:	DMSO
Purity:	>99%
Storage:	Store in a tightly closed container in a cool and dry place
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Pazopanib(GW-786034):

Size	Price	Stock
500mg	USD350	In stock
1g	USD500	In stock

Biological Activity:

Pazopanib(GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.An oral angiogenesis inhibitor targeting VEGFR and PDGFR.A potent and selective inhibitor of tyrosine kinases, targeting VEGFR/c-KIT/PDGFR, blocking angiogenesis; as an oral antineoplastic agent.

References:

1 . Limvorasak S, Posadas EM.Pazopanib: therapeutic developments.Expert Opin Pharmacother. 2009 Dec;10(18):3091-102.
2. LaPlant KD, Louzon PD.Pazopanib: an oral multitargeted tyrosine kinase inhibitor for use in renal cell carcinoma.Ann Pharmacother. 2010 Jun;44(6):1054-60. Epub 2010 Apr 20.
3. Olaussen, K., et al.: Oncogen., 28, 4249 (2009), Sleijfer, S., et al.: J. Clin. Oncol., 27, 3126 (2009), Chan, A., et al.: Drugs, 69, 167 (2009),

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