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C13805 Lenalidomide(CC-5013) (191732-72-6)

Catalog No.:	C13805
CAS No.:	191732-72-6
Synonym:	Revlimid;CC-5013;CC5013;CC 5013
Chemical Name:	3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Molecular Formula:	C₁₃H₁₃N₃O₃
Molecular Weight:	259.26

Technical Data:

Appearance:	Off-white to pale yellow powder
Solubility:	DMSO ≥50mg/mL;Water <1.2mg/mL;Ethanol <1.2mg/mL
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Lenalidomide(CC-5013):

Size	Price	Stock
1g	USD160	In Stock
2g	USD300	In Stock

Biological Activity:

TNF-alpha Inhibitor; Lenalidomide (CC-5013, Revlimid), analogue of thalidomide, a new drug in a group known as ImiDs, with broad cytokine modulatory activity.
Lenalidomide is less toxic than thalidomide without teratogenicity, sedation, or neurotoxicity, and is 50,000-fold more potent in inhibiting, tumor necrosis factor(TNF)-α,
that is involved in the pathophysiology of myelofibrosis (MF).

References:

1. Muller GW, et al. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30.
2. Zangari M, et al. Immunomodulatory drugs in multiple myeloma. Expert Opin Investig Drugs. 2005 Nov;14(11):1411-8.
3. Lopez-Girona A, et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35.

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