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ICONC13812 Leucovorin calcium(Calcium folinate) (1492-18-8)
 
 
Catalog No.: C13812
CAS No.: 1492-18-8
Synonym: Folinic acid calcium salt;Citrovorum factor calcium salt, Leucovorin calcium salt
Chemical Name:

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-HCO-H4PteGlu, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt.
Molecular Formula:

C20H21N7O7.Ca
Molecular Weight: 511.51
 
Technical Data:
Appearance: White or light yellow amorphous crystalline powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Leucovorin calcium(Calcium folinate):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
 
References:

Schilsky RL, Ratain MJ. Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration. J Natl Cancer Inst. 1990 Sep 5;82(17):1411-5.
 
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