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ICONC14364 ZM 447439 (331771-20-1)
 
 
Catalog No.: C14364
CAS No.: 331771-20-1
Synonym: ZM447439; ZM 447439
Chemical Name:

N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazo linyl]amino]phenyl]benzamide
Molecular Formula:

C29H31N5O4
Molecular Weight: 513.59
 
Technical Data:
Appearance: Yellow powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of ZM 447439:

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Biological Activity:

Selective and ATP-competitive inhibitor of Aurora B kinase in vitro, with IC50 values to be 50, 250 and 1000 nM for Aurora B, C and A kinases respectively
 
References:
1. Ditchfield C, et al. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J Cell Biol. 2003 Apr 28;161(2):267-80.
2. Georgieva I, et al. ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio- and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines. Neuroendocrinology. 2010;91(2):121-30.
 
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