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ICONC13441 Carboplatin (41575-94-4)
 
 
Catalog No.: C13441
CAS No.: 41575-94-4
Synonym: NSC241240, Paraplatin, JM8
Chemical Name:

1,1-Cyclobutanedicarboxylatodiammineplatinum (II); Paraplatin; cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)

Molecular Formula:

C6H12N2O4Pt

Molecular Weight: 371.25
 
Technical Data:
Appearance: A white crystalline powder
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Carboplatin:

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin.

 
References:

1. Thomas JP  et al. High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity. Mol Pharmacol 70:23-9 (2006). 

2. Mlcouskova J  et al. Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding. J Biol Inorg Chem 17:891-8 (2012). 

 
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