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ICONC11154 CPT-11(Irinotecan hydrochloride) (100286-90-6)
 
 
Catalog No.: C11154
CAS No.: 100286-90-6
Synonym: Irinotecan, Camptothecin 11
Chemical Name:

(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-d ioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride
Molecular Formula:

C33H38N4O6.HCl
Molecular Weight: 623.14
 
Technical Data:
Appearance: Pale yellow or yellow crystalline powder
Solubility: Soluble in Water
Purity: >99%
Storage: Store at room temperature
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of CPT-11(Irinotecan hydrochloride):

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10mg 

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Contact us for competitive discounts on bulk quantities
 
Biological Activity:

Inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types.
 
References:

1. Albertsson P  et al. Low-dosage metronomic chemotherapy and angiogenesis: topoisomerase inhibitors irinotecan and mitoxantrone stimulate VEGF-A-mediated angiogenesis. APMIS 120:147-56 (2012). 

2. Morton CL  et al. Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice. Cancer Chemother Pharmacol 56:629-36 (2005).
 
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