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ICONC14349 XAV-939(NVP-XAV939) (284028-89-3)
 
 
Catalog No.: C14349
CAS No.: 284028-89-3
Synonym: NVP-XAV939
Chemical Name:

2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol; 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one

Molecular Formula:

C14H11F3N2OS

Molecular Weight: 312.31
 
Technical Data:
Appearance: White solid
Solubility: Soluble in DMSO and Methanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of XAV-939(NVP-XAV939):

Size

Price

Stock

50mg 

USD180

In Stock 

100mg 

USD280

In Stock 

500mg 

Get quote

 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Tankyrase (TNKS) inhibitor, with IC50 values to be 11 and 4 nM for TNKS1 and TNKS2 respectively; inhibiting Wnt / β-catenin signaling; XAV939 is a cell-permeable small molecule inhibitor of the Wnt / β-catenin pathway that inhibits tankyrase 1 and tankyrase 2, thus stabilizing axin and stimulating β-catenin degradation; Current research suggests that Wnt proteins act to maintain stem cells in an undifferentiated, self-renewing state. Wnt proteins act on a variety of stem cells that include neural, mammary and embryonic stem cells. In addition, XAV939 inhibits growth of DLD-1 cells, an APC-deficient colorectal cancer cell line.

 
References:
Sakata T & Chen JK Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways. Chem Soc Rev 40:4318-31 (2011).
 
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