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ICONC14236 Temsirolimus (CCI-779, Torisel)  (162635-04-3)
 
 
Catalog No.: C14236
CAS No.: 162635-04-3
Synonym: Torisel; CCI-779; CCI 779; CCI779
Chemical Name:

Rapamycin 42-[3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate

Molecular Formula:

C56H87NO16

Molecular Weight: 1030.29
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Temsirolimus (CCI-779, Torisel) :

Size

Price

Stock

50mg 

USD180

In Stock 

100mg 

USD330

In Stock 

500mg 

Get quote 

 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Temsirolimus (also known as CCI-779) is a recently developed mTOR inhibitor, with improved aqueous solubility and more favorable pharmaceutical properties compared with the parent compound rapamycin.
Temsirolimus has shown promising preclinical and early clinical antitumor activity and is currently in phase III clinical development for the treatment of different solid tumors, including breast cancer.

 
References:

1. Shuuin T, Karashima H.[Mammalian target of rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma].Gan To Kagaku Ryoho. 2009 Jul;36(7):1076-9.

2. Mounier N, Vignot S, Spano JP.[Update on clinical activity of CCI779 (temsirolimus), mTOR inhibitor].Bull Cancer. 2006 Nov;93(11):1139-43.

 
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