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ICONC14327 Verteporfin(DB00460) (129497-78-5)
 
 
Catalog No.: C14327
CAS No.: 129497-78-5
Synonym: Verteporphin;Visudyne;CL 318,952;Benzoporphyrin D;Bpd-MA;AIDS350621;AIDS-350621
Chemical Name:
trans-3,4-Dicarboxy-4,4a-dihydro-4a,8,14,19-tetramethyl-18-vinyl-23H,25H-benzo(b)porphine-9,13-dipropionic acid 3,4,9-trimethyl ester
Molecular Formula: C41H42N4O8
Molecular Weight: 718.79
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Verteporfin(DB00460):

Size

Price

Stock

10mg 

USD100

In Stock 

50mg 

USD380

In Stock 

100mg 

USD650

In Stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin in endothelial cells.

Verteporfin is about four times more efficient in absorbing light at wavelengths that penetrate tissues best (i.e., around 700 nm) and thus provides a much higher cytotoxic effect than hematoporphyrin (10 times more in human adherent cell lines). Verteporfin is lipophilic and is more readily taken up by malignant or activated cells, compared with normal or resting cells. Verteporfin binds with LDL to form a complex, which is then taken up into proliferating cells (e.g., neovascular endothelial cells) probably via LDL receptors and endocytosis. Verteporfin therapy achieves complete angiographic occlusion of the neovascular compartment by thrombosis of vascular channels, following selective endothelial damage. Verteporfin therapy selectively induces reproducible and isolated choriocapillary occlusion without alteration of overlying photoreceptors or ganglion cells, as shown by light and electron microscopy. Verteporfin conbined with light rapidly exhibits apoptotic changes reflected by caspase-3 and caspase-9 activation and PARP cleavage in HL-60 cells, changes that are blocked by the general caspase inhibitor ZVAD.fmk.

Verteporfin can be used for angiographic visualization of choroidal vessels and CNV, which demonstrates that the photosensitizer accumulates rapidly in experimental CNV in monkeys. Verteporfin accumulates rapidly in the established vasculature of the choroid, RPE, and photoreceptors of rabbit eyes. Verteporfin reaches maximal tissue levels within 3 hours of intravenous injection, followed by a rapid decline within 24 hours in mice. Verteporfin is metabolized to a less active form in vivo and is cleared very rapidly, predominantly in the feces and a very small proportion excreted in urine. Verteporfin therapy effectively and selectively prevents fluorescein dye leakage from experimentally induced CNV in monkeys.

 
References:

1.Schmidt-Erfurth U, et al. Surv Ophthalmol, 2000, 45(3), 195-214.

2.Granville DJ, et al. Blood, 2000, 95(1), 256-262.

 
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