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ICONC10028 6,7-Dihydroxycoumarin (305-01-1)
 
 
Catalog No.: C10028
CAS No.: 305-01-1
Synonym: 6,7-Dihydroxycoumarin; Aesculetin; Cichorigenin
Chemical Name:
6,7-Dihydroxycoumarin
Molecular Formula: C9H6O4
Molecular Weight: 178.14
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO
Purity:
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of 6,7-Dihydroxycoumarin:

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10mg 

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Biological Activity:
Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase; 5-LOX) inhibitor. Esculetin is reported to display antiinflammatory and antioxidant properties, as well as induce cell cycle arrest and apoptosis. In the presence of esculetin and HA14-1 expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. Additionally, reports demonstrate that Esculetin also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
 
References:
1. Neichi, T., et al. 1983. Biochim. Biophys. Acta. 753: 130-132. PMID: 6411127
2. Du, L., et al. 2006. J. Biochem. 139: 715-723. PMID: 16672272
3. Kok, S.H., et al. 2009. Oral Oncol. 45: 1067-1072. PMID: 19720557
4. Witaicenis, A., et al. 2010. Chem. Biol. Interact. 186: 211-218. PMID: 20380826
5. Park, C., et al. 2010. Toxicol In Vitro. 24: 486-494. PMID: 19786087
 
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