ICONHome   ICONContact us   ICONAdd Favorites
Biochemtek
Search Product
Live Chat E-mail
Pharmacology
ICON Inhibitors
ICON Receptors
ICON Hedgehog Signaling Pathway
ICON Stem Cells & Wnt
ICON Signal Transduction
 　 More +
Research Area
ICON Cancer
ICON Antivirus
ICON Cardiovascular System
ICON Endocrinology
ICON Neuroscience
 　 More +
Product Type
ICON Natural Products
ICON Peptides
ICON Prostaglandins
ICON Vitamin D series compounds
ICON Toxins
 　 More +
Browse Alphabetically by Name
ALL A B C D E F
G H I J K L M
N O P Q R S T
U V W X Y Z Others
 
ICONC10958 Genipin (6902-77-8)
 
 
Catalog No.: C10958
CAS No.: 6902-77-8
Synonym: (+)-Genipin;Methyl (1S,2R,6S)-2-hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate
Chemical Name:

1,4a,5,7a-Tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta(c)pyran-4-carboxylic acid methyl ester
Molecular Formula:

C11H14O5
Molecular Weight: 226.2
 
Technical Data:
Appearance: White needle crystals
Solubility: Soluble in DMSO, methanol, acetone and ethyl acetate, insoluble in water
Purity: >99%
Storage: at -20℃
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Genipin:

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities
 
Biological Activity:

Cell permeable inhibitor of uncoupling protein 2 (UCP2). Increases glucose-stimulated insulin secretion, mitochondrial membrane potential and ATP levels in pancreatic island cells. Induces apoptosis. Protein cross-linking agent. Anti-inflammatory and anti-angiogenic
 
References:
1.Ma C, Nie A, Zhang Z, et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20.
2. Parton LE, Ye CP, Coppari R et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007 Sep 13;449(7159):228-32.
3. Zhang CY, Parton LE, Ye CP, et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab. 2006 Jun;3(6):417-27.
 
View Related Products by Target:
Vandetanib(AZD6474)
Vorinostat(SAHA)
Tozasertib(VX-680)
Lenalidomide(CC-5013)
Teniposide(VM-26)
Pazopanib(GW-786034)
Trilostane
CYC-116
Gemcitabine HCL
Bicalutamide
Sorafenib Tosylate
Sunitinib Malate(Sutent)
 
 

Keywords: Buy Genipin | Genipin Supplier | Purchase Genipin | Genipin Cost | Genipin  Manufacturer | Order Genipin | Genipin Distributor | Genipin Structure, Chembest

Buy 6902-77-8| 6902-77-8 Supplier | Purchase 6902-77-8 | 6902-77-8 Cost | 6902-77-8 Manufacturer | Order 6902-77-8 | 6902-77-8 Distributor | 6902-77-8 Structure, Chembest  
Products are for research use only. Not for human use. We do not sell to patients.
Copyright © 2010-2013 Chembest Research Laboratories. All Rights Reserved
E-mail:sales@biochembest.com