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ICONC10255 Betulinic acid  (472-15-1)
 
 
Catalog No.: C10255
CAS No.: 472-15-1
Synonym: Lupatic acid; Betulic acid; Mairin
Chemical Name:

3beta-Hydroxy-20(29)-lupaene-28-oic acid

Molecular Formula:

C30H48O3

Molecular Weight: 456.71
 
Technical Data:
Appearance: White to off-white powder
Solubility: Soluble in DMSO
Purity: >98%
Storage: at +4°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Betulinic acid :

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10mg 

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Biological Activity:

Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator. Triggers CD95- and p53-independent apoptosis via activation of caspases. It induces mitochondrial permeability pore opening and the release of cytochrome c and apoptosis-inducing factor. Displays anti-HIV activity. EC50 for inhibion of HIV-1 replicaton in H9 lymphocytes: 1.4µM

 
References:
1.Fulda S, Scaffidi C, Susin SA et al. Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem. 1998 Dec 18;273(51):33942-8.

2. Chowdhury AR, Mandal S, Mittra B, et al. Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives. Med Sci Monit. 2002 Jul;8(7):BR254-65.
 
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