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ICONC13518 Cyclosporin D (63775-96-2)
 
 
Catalog No.: C13518
CAS No.: 63775-96-2
Synonym: Val2-cyclosporine
Chemical Name:

Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl]

Molecular Formula:

C63H113N11O12

Molecular Weight: 1216.66
 
Technical Data:
Appearance: Colorless Prisms
Solubility: Soluble in ethanol
Purity: >98%
Storage: at room temperature
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Cyclosporin D:

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Biological Activity:

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A-cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxid.

 
References:
Bell A  et al. Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochem Pharmacol 48:495-503 (1994).
 
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