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C13634 Equol (531-95-3)

Catalog No.:	C13634
CAS No.:	531-95-3
Synonym:	4',7-Isoflavandiol
Chemical Name:	3,4-Dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol, 4’,7-Dihydroxyisoflavane
Molecular Formula:	C₁₅H₁₄O₃
Molecular Weight:	242.3

Technical Data:

Appearance:	Off white or pale yellow solid
Solubility:	Soluble in DMSO and Methanol
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Equol :

Size	Price	Stock
10mg	USD	In Stock
50mg	USD	In Stock
100mg	USD	In Stock

Biological Activity:

Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein. (S)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM). (S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.

References:

1.Muthyala RS, et al. Bioorg Med Chem, 2004, 12(6), 1559-1567.

2. Setchell KD, et al. J Nutr, 2002, 132(12), 3577-3584.

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