ICONHome   ICONContact us   ICONAdd Favorites
Biochemtek
Search Product
Live Chat E-mail
Pharmacology
ICON Inhibitors
ICON Receptors
ICON Hedgehog Signaling Pathway
ICON Stem Cells
ICON Signal Transduction
   More +
Research Area
ICON Cancer
ICON Antivirus
ICON Cardiovascular System
ICON Endocrinology
ICON Neuroscience
   More +
Product Type
ICON Natural Products
ICON Peptides
ICON Prostaglandins
ICON Vitamin D series compounds
ICON Toxins
   More +
Browse Alphabetically by Name
ALL A B C D E F
G H I J K L M
N O P Q R S T
U V W X Y Z Others
 
ICONC14300 TW-37  (877877-35-5)
 
 
Catalog No.: C14300
CAS No.: 877877-35-5
Synonym: TW-37
Chemical Name:
N-[4-[(2-tert-Butylphenyl)sulfonyl]phenyl]-2,3,4-trihydroxy-5-[(2-isopropylphenyl)methyl]benzamide
Molecular Formula:

C33H35NO6S

Molecular Weight: 573.7
 
Technical Data:
Appearance: White solid
Solubility: Soluble in DMSO
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of TW-37 :

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

TW-37 binds to the BH3 binding groove in Bcl-2 protein competing with BH3 peptides derived from Bid, Bim, and Bad proteins. TW-37 binds to Bcl-2 with a K(i) value of 290 nM and also to Bcl-xL and Mcl-1 with high affinities.TW-37 potently inhibits cell growth in PC-3 prostate cancer cells with an IC50 value of 200 nM and effectively induces apoptosis in a dose-dependent manner. TW-37 has an IC50 of 1.1 µmol/L for primary human endothelial cells and averaged 0.3 µmol/L for head and neck cancer cells (OSCC3,UM-SCC-1, and UMSCC-74A). The combination of TW-37 and cisplatin showed enhanced cytotoxic effects for endothelial cells and HNSCC in vitro, compared with single drug treatment.

 
References:
1.Mohammad RM, et al. Clin Cancer Res, 2007, 13(7), 2226-2235.

2. Zeitlin BD, et al. Cancer Res, 2006, 66(17), 8698-8706.

 
View Related Products by Target:
Vandetanib(AZD6474)
Vorinostat(SAHA)
Tozasertib(VX-680)
Lenalidomide(CC-5013)
Teniposide(VM-26)
Pazopanib(GW-786034)
Trilostane
CYC-116
Gemcitabine HCL
Bicalutamide
Sorafenib Tosylate
Sunitinib Malate(Sutent)
 
 

Keywords: Buy TW-37 | TW-37 Supplier | Purchase TW-37 | TW-37 Cost | TW-37  Manufacturer | Order TW-37 | TW-37 Distributor | TW-37 Structure, Chembest

Buy 877877-35-5| 877877-35-5 Supplier | Purchase 877877-35-5 | 877877-35-5 Cost | 877877-35-5 Manufacturer | Order 877877-35-5 | 877877-35-5 Distributor | 877877-35-5 Structure, Chembest  

Products are for research use only. Not for human use. We do not sell to patients.
Copyright © 2010-2013 Chembest Research Laboratories. All Rights Reserved
E-mail:sales@biochembest.com