ICONHome   ICONContact us   ICONAdd Favorites
Biochemtek
Search Product
Live Chat E-mail
Pharmacology
ICON Inhibitors
ICON Receptors
ICON Hedgehog Signaling Pathway
ICON Stem Cells
ICON Signal Transduction
   More +
Research Area
ICON Cancer
ICON Antivirus
ICON Cardiovascular System
ICON Endocrinology
ICON Neuroscience
   More +
Product Type
ICON Natural Products
ICON Peptides
ICON Prostaglandins
ICON Vitamin D series compounds
ICON Toxins
   More +
Browse Alphabetically by Name
ALL A B C D E F
G H I J K L M
N O P Q R S T
U V W X Y Z Others
 
ICONC13988 PD 0325901 (391210-10-9)
 
 
Catalog No.: C13988
CAS No.: 391210-10-9
Synonym: PD-0325901,MEK1/2 Inhibitor III
Chemical Name:

N-[((R)-2,3-Dihydroxypropyl)oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

Molecular Formula:

C16H14F3IN2O4

Molecular Weight: 482.19
 
Technical Data:
Appearance: White solid
Solubility: Soluble in ethanol, DMSO & methyl formamide
Purity: >99%
Storage: Store at -20°C
Original QC Data:
Shipping Conditions: Soluble in DMSO
 
Price and Availability of PD 0325901:

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

PD0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. PD0325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation.

 
References:

Sheth PR  et al. Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901. Biochemistry 50:7964-76 (2011).

 
View Related Products by Target:
Vandetanib(AZD6474)
Vorinostat(SAHA)
Tozasertib(VX-680)
Lenalidomide(CC-5013)
Teniposide(VM-26)
Pazopanib(GW-786034)
Trilostane
CYC-116
Gemcitabine HCL
Bicalutamide
Sorafenib Tosylate
Sunitinib Malate(Sutent)
 
 

Keywords: Buy PD 0325901 | PD 0325901 Supplier | Purchase PD 0325901 | PD 0325901 Cost | PD 0325901  Manufacturer | Order PD 0325901 | PD 0325901 Distributor | PD 0325901 Structure, Chembest

Buy 391210-10-9| 391210-10-9 Supplier | Purchase 391210-10-9 | 391210-10-9 Cost | 391210-10-9 Manufacturer | Order 391210-10-9 | 391210-10-9 Distributor | 391210-10-9 Structure, Chembest  

Products are for research use only. Not for human use. We do not sell to patients.
Copyright © 2010-2013 Chembest Research Laboratories. All Rights Reserved
E-mail:sales@biochembest.com