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C13395 Bortezomib (179324-69-7)

Catalog No.:	C13395
CAS No.:	179324-69-7
Synonym:	Velcade, MG-341, PS-341
Chemical Name:	[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-boronic acid; Velcade; DPBA
Molecular Formula:	C₁₉H₂₅BN₄O₄
Molecular Weight:	384.24

Technical Data:

Appearance:	White or off-white crystalline powder
Solubility:	Soluble in DMSO and Methanol
Purity:	>99%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of Bortezomib:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

The first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome, which is a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells.

References:

1. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22.

2. Boccadoro M, et al. Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy. Cancer Cell Int. 2005 Jun 1;5(1):18.

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