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ICONC13462 CT 99021(CHIR 99021) (252917-06-9)
 
 
Catalog No.: C13462
CAS No.: 252917-06-9
Synonym: CHIR 99021
Chemical Name:

6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile

Molecular Formula: C22H18Cl2N8
Molecular Weight: 465.35
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >98%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of CT 99021(CHIR 99021):

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Price

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10mg 

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25mg 

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In Stock 

50mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:

A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). CHIR99021 exhibits little to no activity toward 46 other enzymes (IC50>8.8 µM against 20 kinases and Kι ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). CHIR99021 is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo.

 
References:
Ye S  et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One 7:e35892 (2012).
 
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