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ICONC13991 PD 184352(CI-1040) (212631-79-3)
 
 
Catalog No.: C13991
CAS No.: 212631-79-3
Synonym: CI-1040
Chemical Name:

2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

Molecular Formula:

C17H14ClF2IN2O2

Molecular Weight: 478.66
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Ethanol
Purity: >99%
Storage: at +4°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of PD 184352(CI-1040):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:

PD184352 is a MEK inhibitor (IC50 = 10-100 nM), a kinase upstream in the mitogen-activated protein kinase pathway (MAPK). Inhibition of MEK leads to a reduction of MAPK activation, suppressing colon tumor proliferation in mice with limited organism toxicity.

 
References:

1. Cossa G  et al. Differential outcome of MEK1/2 inhibitor-platinum combinations in platinum-sensitive and -resistant ovarian carcinoma cells. Cancer Lett 347:212-24 (2014).

2. Allen LF  et al. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol30:105-16 (2003). 

 
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