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Biological Activity:
Analogue of Ritonavir and selective HIV protease inhibitor; Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class. As a component of combination therapy to treat HIV/AIDS. Inhibition of HIV-1 protease prevents cleavage of the viral polyprotein precursor and results in the release of immature, noninfectious virions.
References:
Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)