Buy (S)-10-Hydroxycamptothecin|19685-09-7|Inhibitors|from supplier chembestbuy.com|Research only

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C12535 (S)-10-Hydroxycamptothecin (19685-09-7)

Catalog No.:	C12535
CAS No.:	19685-09-7
Synonym:	10-Hydroxycamptothecin
Chemical Name:	(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 10-Hydroxycamptothecin; 10-Hydroxycamptothecine; NSC 107124
Molecular Formula:	C₂₀H₁₆N₂O₅
Molecular Weight:	364.35

Technical Data:

Appearance:
Solubility:	Soluble in DMSO and Ethanol
Purity:	>98%
Storage:	at -20℃ 2 years
Original QC Data:
Shipping Conditions:	Ambient Temp.

Price and Availability of (S)-10-Hydroxycamptothecin:

Size	Price	Stock
10mg	USD	In stock
50mg	USD	In stock
100mg	USD	In stock

Biological Activity:

DNA topoisomerase I inhibitor (IC₅₀ = 106 nM). Cytotoxic antitumour compound, more potent than camptothecin. In vitro and in vivo activity against a broad spectrum of cancers.

References:

1. Hu W et al. Anticancer properties of 10-hydroxycamptothecin in a murine melanoma pulmonary metastasis model in vitro and in vivo. Toxicol In Vitro 25:513-20 (2011).

2. Ping YH et al. Anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. Oncol Rep15:1273-9 (2006).

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