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ICONC13545 Decitabine(NSC127716) (2353-33-5)
 
 
Catalog No.: C13545
CAS No.: 2353-33-5
Synonym: 2'-Deoxy-5-azacytidine, 5-Aza-2'-deoxycytidine;Dezocitidine
Chemical Name:

5-Aza-2'-deoxycytidine; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one

Molecular Formula:

C8H12N4O4

Molecular Weight: 228.21
 
Technical Data:
Appearance: White to off white crystalline powder
Solubility: Soluble in DMSO
Purity: >99%
Storage: Store at +4°C
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of Decitabine(NSC127716):

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10mg 

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50mg 

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100mg 

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Contact us for competitive discounts on bulk quantities

 
Biological Activity:

Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation.

 
References:

Shin DY  et al. Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation. Int J Oncol 41:910-8 (2012).

 
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