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ICONC13705 GDC-0449(Vismodegib) (879085-55-9)
 
 
Catalog No.: C13705
CAS No.: 879085-55-9
Synonym: RG-3616,Vismodegib,HhAntag691
Chemical Name:

2-Chloro-N-(4-chloro-3-pyridin-2-yl-phenyl)-4-methanesulfonyl-benzamide

Molecular Formula:

C19H14Cl2N2O3S

Molecular Weight: 421.3
 
Technical Data:
Appearance:
Solubility: Soluble in DMSO and Methanol
Purity: >99%
Storage: at -20℃ 2 years
Original QC Data:
Shipping Conditions: Ambient Temp.
 
Price and Availability of GDC-0449(Vismodegib):

Size

Price

Stock

10mg 

USD

In stock 

50mg 

USD

In stock 

100mg 

USD

In stock 

Contact us for competitive discounts on bulk quantities

 
Biological Activity:

The first-in-class inhibitor of Hedgehog (Hh) signaling pathway; more specifically, an orally bioavailable and potent inhibitor of smoothened homologue (SMO); an investigational anti-cancer drug for Medulloblastoma, advanced basal cell skin cancer etc.

 
References:
Scales SJ, et al. Trends Pharmacol Sci. 2009, 30(6), 303-312.
 
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